Peter Jenkins, a Raccoon University professor, the two developed a vaccine effective even against Umbrella's modified ε strain, which was dubbed ' Daylight'.

Mueller objected to Umbrella's interest in cloning Thanatos for mass-production in August 1998, and began working against the company. With Raccoon University lying on top of unused facilities, this became a prime space for research and storage of bioweaponry, and it was here that the ' Thanatos' began development as an experimental next-step in research following the mass-production of the T-103 series.

He thereafter performed an operation on her to affect her memories, an action that took until October 1998 to reverse. In 1996 he was able to use a student, Yoko Suzuki, in t-Virus trials. Alongside his work with Umbrella, Mueller also worked at Raccoon University. He was already involved in the t-Virus Project in 1993, when he was the banker in an illegal human research trial conducted at a hospital in the Arklay Mountains, wherein patients were infected with a t-Virus variant with anti-carcinogenic properties. Mueller worked at the Umbrella R&D Center in Raccoon City.

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